A single-dose comparison of four slow-release theophylline preparations in normal subjects. Issue 665 (March 1981)

• Record Type: Journal Article
• Authors: Sharma, J. N.; Blackett, A.; Johnston, A.; Hathway, N. R.
• Is Part Of: Postgraduate medical journal. Volume 57:Issue 665(1981)
• Page Start: 153
• Page End: 155
• Publication Date: 1981-03
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.57.665.153
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : The plasma theophylline concentrations produced by 4 different slow release formulations, Theograd, Theodur, Theolair-SR and Rona-slophylline were measured over a 24-hr period in 8 healthy subjects. All 4 preparations maintained plasma levels over 12 hr and had similar AUC values when the difference in theophylline content was taken into account. Paired saliva and plasma theophylline concentrations gave a ratio of 1: 0·38, saliva: plasma, but with a large inter and intra individual variation.