The platelet defect in acute myeloid leukaemia. Issue 12 (December 1984)

• Record Type: Journal Article
• Authors: Woodcock, B E; Cooper, P C; Brown, P R; Pickering, C; Winfield, D A; Preston, F E
• Is Part Of: Journal of clinical pathology. Volume 37:Issue 12(1984)
• Page Start: 1339
• Page End: 1342
• Publication Date: 1984-12
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.37.12.1339
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : In a study of platelets from 13 patients with acute myeloid leukaemia abnormal aggregation and release reactions were found. A previously unrecognised quantitative defect of thromboxane B2 production may, at least in part, explain these findings. In contrast to a previous report, we were unable to show a convincing storage pool defect in these platelets. The platelet membrane glycoproteins were largely normal.