Site-selective desaturation of C(sp3)–C(sp3) bonds via photoinduced ruthenium catalysis. Issue 16 (4th July 2022)

• Record Type: Journal Article
• Authors: Wang, Chuanyong; Xing, Zhongqiu; Ge, Qiangqiang; Yu, Yangyang; Wang, Minyan; Duan, Wei-Liang
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 16(2022)
• Page Start: 4316
• Page End: 4327
• Publication Date: 2022-07-04
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00332e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient desaturation and 1, 5-HAT/Heck-type coupling reaction has been developed in a highly regio- and stereoselective fashion via photo-induced Ru catalysis. Abstract : Ruthenium(ii ) photocatalysis has emerged as one of the most advanced tools in modern synthetic chemistry, but its catalytic mode is generally limited to single-electron transfer and triplet energy transfer events. Herein, we introduce a dual function ruthenium(ii ) catalytic system by intertwining single-electron transfer with its innate transition metal catalytic activity. This approach allows for the efficient desaturation of various amide and alcohol derivatives in a highly regio- and stereoselective fashion under mild conditions. Further, an interesting radical-triggered cascade 1, 5-HAT/Heck-type coupling could also be achieved through this photoinduced Ru catalysis.