Microfabrication of peptide self-assemblies: inspired by nature towards applications. (21st July 2022)

• Record Type: Journal Article
• Authors: Zhang, Jiahao; Wang, Yancheng; Rodriguez, Brian J.; Yang, Rusen; Yu, Bin; Mei, Deqing; Li, Junbai; Tao, Kai; Gazit, Ehud
• Is Part Of: Chemical Society reviews. Volume 51:Number 16(2022)
• Page Start: 6936
• Page End: 6947
• Publication Date: 2022-07-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cs00122e
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : In this review, the development of microfabrication of peptide self-assemblies, including methodologies along with the diverse properties and applications of the engineered large-scale, highly-ordered peptide arrays, are summarized. Abstract : Peptide self-assemblies show intriguing and tunable physicochemical properties, and thus have been attracting increasing interest over the last two decades. However, the micro/nano-scale dimensions of the self-assemblies severely restrict their extensive applications. Inspired by nature, to genuinely realize the practical utilization of the bio-organic super-architectures, it is beneficial to further organize the peptide self-assemblies to integrate the properties of the individual supermolecules and fabricate higher-level organizations for smart functional devices. Therefore, cumulative studies have been reported on peptide microfabrication giving rise to diverse properties. This review summarizes the recent development of the microfabrication of peptide self-assemblies, discussing each methodology along with the diverse properties and practical applications of the engineered peptide large-scale, highly-ordered organizations. Finally, the current limitations of the state-of-the-art microfabrication strategies are critically assessed and alternative solutions are suggested.