Comparison of the diagnostic performance of shear wave elastography with shear wave dispersion for pre-operative staging of hepatic fibrosis in patients with hepatocellular carcinoma. Issue 154 (September 2022)

• Record Type: Journal Article
• Authors: Wang, Kun; Yu, Dong; Li, Gaofeng; Wen, Li; Zhang, Shuchen
• Is Part Of: European journal of radiology. Issue 154(2022)
• Publication Date: 2022-09
• Subjects: Shear wave elastography -- Shear wave dispersion -- Hepatic fibrosis -- Ultrasound; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2022.110459
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Shear wave dispersion (SWD) is a novel ultrasound-based imaging technique. In this prospective study, we compared the diagnostic performance of SWE with that of SWD in evaluation of hepatic fibrosis in patients with hepatocellular carcinoma before resection. Abstract: Purpose: This prospective study aimed to compare the diagnostic accuracy of shear wave elastography (SWE) with that of shear wave dispersion (SWD) in evaluation of hepatic fibrosis in patients with hepatocellular carcinoma before resection. Method: A total of 210 consecutive patients with hepatocellular carcinoma (HCC) who were scheduled to undergo hepatectomy were prospectively enrolled, pre-operative SWE and SWD examinations were performed. Fibrosis staging and necroinflammatory activity were determined histopathologically according to the Scheuer standard. Multivariate linear regression analysis was used to identify factors associated with SWE and SWD values. The performance of SWE and SWD were determined by receiver operating characteristic (ROC) analysis. Results: Both SWE and SWD values of liver were highly correlated with liver fibrosis stage and necroinflammatory activity ( p < 0.05). Both SWE and SWD values were significantly different among the patients with different stages of liver fibrosis ( p < 0.001). ROC analysis revealed that SWE that predicted substantial fibrosis (S ≥ 2), severe fibrosis (S ≥ 3) and cirrhosis (S = 4) were 0.895, 0.877 and 0.854, the SWD that predicted substantial fibrosis (S ≥ 2), severe fibrosis (S ≥ 3) and cirrhosis (S = 4) were 0.857, 0.815 and 0.791. SWE had better diagnostic performance than SWD in predicting severe fibrosis (S ≥ 3) and cirrhosis (S = 4). Conclusions: Both SWE and SWD are useful, accurate and non-invasive methods for evaluating hepatic fibrosis in patients with hepatocellular carcinoma adapted to hepatectomy, SWE is a more accurate imaging modality than SWD in predicting severe fibrosis (S ≥ 3) and cirrhosis (S = 4).