Identification of atrial fibrillation drivers by means of concentric ring electrodes. (September 2022)

• Record Type: Journal Article
• Authors: Prats-Boluda, Gema; Guillem, María S.; Rodrigo, Miguel; Ye-Lin, Yiyao; Garcia-Casado, Javier
• Is Part Of: Computers in biology and medicine. Volume 148(2022)
• Publication Date: 2022-09
• Subjects: Atrial fibrillation -- AF driver -- Surface Laplacian potential -- Concentric ring electrodes; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2022.105957
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Background and objective: The prevalence of atrial fibrillation (AF) has tripled in the last 50 years due to population aging. High-frequency (DFdriver) activated atrial regions lead the activation of the rest of the atria, disrupting the propagation wavefront. Fourier based spectral analysis of body surface potential maps have been proposed for DFdriver identification, although these approaches present serious drawbacks due to their limited spectral resolution for short AF epochs and the blurring effect of the volume conductor. Laplacian signals (BC-ECG) from bipolar concentric ring electrodes (CRE) have been shown to outperform the spatial resolution achieved with conventional unipolar recordings. Our aimed was to determine the best DFdriver estimator in endocardial electrograms and to assess the BC-ECG capacity of CRE to quantify AF activity non-invasively. Methods: 31 AF episodes were simulated using realistic tridimensional models of the atria electrical activity and torso. Periodogram and autoregressive (AR) spectral estimators were computed and the percentile (P90 th, P95 th and P98 th ) to impose on the dominant frequencies (DFs) across whole atria to define the best DFdriver estimator evaluated. The identification of DFdriver on DFs from BC-ECG and unipolar surface signals with conventional disc electrodes was compared. Results: The best DFdriver estimator was P95 th and AR order 100. BC-ECG signals allowed better detection of AF activity than unipolar signals, with a significantly greater percentage of electrode locations in which DFdriver was identified (p-value 0.0095). Conclusions: The use of BC-ECG signals for body surface Laplacian potential mapping with CRE could be helpful for better AF diagnosis, prognosis and ablation procedures than those with conventional disk electrodes. Highlights: P95 th of DFs in EGMs from spectral AR100 is the best estimator of DFdriver during AF. Concentric ring electrodes (CRE) can detect AF in surface ECG signals. CRE-ECG signals surpass conventional recordings in surface AF characterization. CRE body surface Laplacian Mapping could be helpful in AF diagnosis.