Impact of PI-QUAL on PI-RADS and cancer yield in an MRI-TRUS fusion biopsy population. Issue 154 (September 2022)

• Record Type: Journal Article
• Authors: Pötsch, N.; Rainer, E.; Clauser, P.; Vatteroni, G.; Hübner, N.; Korn, S.; Shariat, S.F.; Helbich, T.H.; Baltzer, P.A.T.
• Is Part Of: European journal of radiology. Issue 154(2022)
• Publication Date: 2022-09
• Subjects: Prostate cancer -- MRI of the prostate -- Image quality -- Diagnostic performance -- PI-QUAL; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2022.110431
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Inter- and intra-reader agreement for diagnostic image quality assessed by PI-QUAL is only moderate. The PI-QUAL rating has limited impact on PI-RADS diagnostic performance in MRI-TRUS fusion biopsy patients. The lower cancer prevalence in lower PI-QUAL categories points out a higher risk of unnecessary biopsies if prostate imaging quality is low. Abstract: Purpose: To test the inter-reader agreement of the Prostate Imaging Quality (PI-QUAL) score for multiparametric prostate MRI and its impact on diagnostic performance in an MRI-ultrasound fusion biopsy population. Patients and methods: Pre-biopsy multiparametric (T2-weighted, DWI, and DCE) prostate MRIs (mpMRI) of 50 patients undergoing transrectal ultrasound-guided MRI-fusion (MRI-TRUS) biopsy were included. Two radiologists independently assigned a PI-QUAL score to each patient and assessed the diagnostic quality of individual sequences. PI-RADS categories were assigned to six regions per prostate (left and right: base/mid-glandular/apex). Inter-reader agreement was calculated using Cohen's kappa and diagnostic performance was compared by the area under the receiver operating characteristics curve (AUC). Results: In 274 diagnostic areas, the malignancy rate was 62.7% (22.5% clinically significant prostate cancer, ISUP ≥ 2). Inter-reader agreement for the diagnostic quality was poor for T2w (kappa 0.19), fair for DWI and DCE (kappa 0.23 and 0.29) and moderate for PI-QUAL (kappa 0.51). For PI-RADS category assignments, inter-reader agreement was very good (kappa 0.86). Overall diagnostic performance did not differ between studies with a PI-QUAL score > 3 compared to a score ≤ 3 (p = 0.552; AUC 0.805 and 0.839). However, the prevalence of prostate cancer was significantly lower when the PI-QUAL score was ≤ 3 (16.7% vs. 30.2%, p = 0.008). Conclusion: PI-QUAL has only a limited impact on PI-RADS diagnostic performance in patients scheduled for MRI-TRUS fusion biopsy. However, the lower cancer prevalence in the lower PI-QUAL categories points out a risk of false-positive referrals and unnecessary biopsies if prostate imaging quality is low.