Highly enantioselective Ni-catalyzed asymmetric hydrogenation of β, β-disubstituted acrylic acids. Issue 16 (15th July 2022)

• Record Type: Journal Article
• Authors: Xiao, Guiying; Xie, Chaochao; Guo, Qianling; Zi, Guofu; Hou, Guohua; Huang, Yuping
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 16(2022)
• Page Start: 4472
• Page End: 4477
• Publication Date: 2022-07-15
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00652a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A highly enantioselective Ni-catalyzed hydrogenation of β, β-disubstituted acrylic acids was first realized using Ph-BPE, providing straightforward access to chiral carboxylic acids in high yields with excellent enantioselectivities, up to 99% ee. Abstract : A highly enantioselective Ni-catalyzed hydrogenation of β, β-disubstituted acrylic acids was first realized using Ph-BPE, providing straightforward access to chiral carboxylic acids in high yields with excellent enantioselectivities, up to 99% ee. The method was successfully applied to not only prepare chiral 3-substituted 1-indanones and chiral alcohols including 3-methyl-1-indanol bearing two chiral centers with high enantio- and diastereoselectivities, but also synthesize the significant intermediate for the oral nonsteroidal androgen receptor agonist pharmaceutical LG 121071.