Historical and new insights into pathogenesis of type 1 diabetes (2). (23rd April 2021)

• Record Type: Journal Article
• Authors: Wong, F S; Tree, T I
• Is Part Of: Clinical and experimental immunology. Volume 204:Number 2(2021)
• Page Start: 165
• Page End: 166
• Publication Date: 2021-04-23
• Subjects: Immunopathology -- Periodicals; 616.079
• DOI: 10.1111/cei.13597
• Languages: English
• ISSNs: 0009-9104

Abstract

Summary: In this second and final part of the collection of articles for the Immunology of Diabetes Society review series on insights into pathogenesis of type 1 diabetes, we present two articles. The first of these covers a debate that took place in the Immunology of Diabetes Society meeting in London 2018, in which five investigators presented a case for specific immune cells/targets to be the 'Achilles Heel of type 1 diabetes'. The second article presents further insights into the generation of post-translationally modified peptides. It focuses upon mechanisms and processes that lead to new potentially autoantigenic targets for CD8 + T cells, and complements the review of new hybrid peptide targets for CD4 + T cells in the first part of our series.