Human papillomavirus genotype distribution of genital keratotic lesions. (11th May 2022)

• Record Type: Journal Article
• Authors: Seong, Seol Hwa; Jeong, Sun Mun; Jung, Jang Hwan; Kwon, Do Ik; Jang, Ji Yun; Kim, Joon Hee; Park, Jong Bin; Baek, Jae Woo; Suh, Kee Suck; Jang, Min Soo
• Is Part Of: Australasian journal of dermatology. Volume 63:Number 3(2022)
• Page Start: e238
• Page End: e243
• Publication Date: 2022-05-11
• Subjects: bowenoid papulosis -- condyloma acuminatum -- genital seborrheic keratosis -- human papillomavirus; Dermatology -- Periodicals; Dermatology -- Australasia -- Periodicals; 616.5005
• DOI: 10.1111/ajd.13867
• Languages: English
• ISSNs: 0004-8380

Abstract

Abstract: Genital keratotic lesions include bowenoid papulosis (BP), which histologically resembles squamous cell carcinoma in situ containing high‐risk HPV, condyloma acuminatum (CA) that is a genital wart containing mostly low‐risk HPV, and genital seborrheic keratosis (GSK), which is a benign epidermal tumour lacking a clear etiologic relationship with HPV. This study compared HPV genotype distributions among BP, CA and GSK and revealed that BP and GSK were related to high‐risk HPV whereas CA was related to low‐risk HPV. It is plausible that GSK is a distinct epidermal tumour often related to high‐risk HPV rather than merely a senescent form of CA considering the overall discrepancy in the frequency distribution of HPV genotypes along with histopathological differences, and the detection of high‐risk HPV in GSK alerts physicians to consider more active treatment and continued follow‐ups.