The design for autologous bone marrow mesenchymal stem cells combined with nano-graphene material in the treatment of neuropathic pain model mice. (September 2022)

• Record Type: Journal Article
• Authors: Li, Ran; Lin, Jiansheng; Zheng, Feng
• Is Part Of: Materials & design. Volume 221(2022)
• Publication Date: 2022-09
• Subjects: Bone marrow mesenchymal stem cells -- Nano-graphene -- Neuropathic pain -- Treatment; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2022.110954
• Languages: English
• ISSNs: 0264-1275

Abstract

Graphical abstract: Highlights: Novel graphene-based neural stem cells have emerged as possible clinical treatments for neural degeneration. The integration of graphene-based nanomaterials and autologous neural stem cells provides a microenvironment that can be manipulated to suit the transplanted cells and can directionally regulate the adhesion, proliferation, and differentiation of the neural stem cells. To clarify the effect of autologous bone marrow mesenchymal stem cell transplantation on spinal cord injury mouse neuropathic pain. The associated mechanism of autologous stem cell transplantation treatment of neuropathic pain on the expression changes of central nerve p2x4 and p2x7 receptors and GDNF receptors. Both BMSCs and endogenous neural stem cells play important roles in SCI repair. Abstract: Stem cell therapy provides a new way for central nervous system function reconstruction and nerve regeneration. In this study, the effect of mobilizing autologous bone marrow mesenchymal stem cells (BMSCs) on neural repair in an animal model of spinal cord injury (SCI). In this study, using a more convenient and efficient in vivo automatic homing method, combining nanomaterials may have integrated topographic and electrical effects on neural stem cell migration and differentiation. The effect and related mechanism of graphene nanomaterials combined with autologous BMSC transplantation in the treatment of neuropathic pain caused by spinal cord injury. Our study show Prove that the BMSCs successfully colonize and secrete neurotrophic factors. In the golden period of early repair of nerve injury, the use of a new graphene to guide the proliferation and differentiation of autologous BMSC to achieve the continuation of nerve regeneration, may complete the function and accelerate the recovery and reduce the occurrence of neuropathic pain.