The 40-Hz auditory steady-state response in bipolar disorder: A meta-analysis. (September 2022)

• Record Type: Journal Article
• Authors: Jefsen, Oskar Hougaard; Shtyrov, Yury; Larsen, Kit Melissa; Dietz, Martin J.
• Is Part Of: Clinical neurophysiology. Volume 141(2022)
• Page Start: 53
• Page End: 61
• Publication Date: 2022-09
• Subjects: Bipolar disorder -- Electroencephalography -- Magnetoencephalography -- Gamma rhythm -- Meta-analysis -- Systematic review; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2022.06.014
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Bipolar disorder (BD) is characterized by aberrant neurophysiological responses in the gamma range. Systematic review and meta-analysis shows reduced 40 Hz auditory steady-state responses (ASSR) in BD. 40-Hz ASSR deficits may represent a transdiagnostic biomarker of neuronal circuit dysfunction. Abstract: Objective: Bipolar disorder is characterized by aberrant neurophysiological responses as measured with electroencephalography (EEG) and magnetoencephalography (MEG), including the 40-Hz auditory steady-state response (ASSR). 40-Hz ASSR deficits are also found in patients with schizophrenia and may represent a transdiagnostic biomarker of neuronal circuit dysfunction. In this systematic review and meta-analysis, we summarize and evaluate the evidence for 40-Hz ASSR deficits in patients with bipolar disorder. Methods: We identified studies from PubMed, EMBASE, and SCOPUS. We assessed the risk of bias, calculated Hedges' g meta-level effect sizes, and investigated small-study effects using funnel plots and Egger regression. Results: Seven studies, comprising 396 patients with bipolar disorder and 404 healthy controls, were included in the meta-analysis. Studies displayed methodological heterogeneity and an overall high risk of bias. Patients with bipolar disorder showed consistent reductions in 40-Hz ASSR evoked power (Hedges' g = −0.49; 95% confidence intervals [−0.67, −0.31]) and inter-trial phase coherence (ITPC) (Hedges' g = −0.43; 95 %CI [−0.58, −0.29]) compared with healthy controls. Conclusions: Our meta-analysis provides evidence that 40-Hz ASSRs are reduced in patients with bipolar disorder compared with healthy controls. Significance: Future large-scale studies are warranted to link 40-Hz ASSR deficits to clinical features and developmental trajectories.