Accurate assessment of the lung sliding artefact on lung ultrasonography using a deep learning approach. (September 2022)

• Record Type: Journal Article
• Authors: VanBerlo, Blake; Wu, Derek; Li, Brian; Rahman, Marwan A.; Hogg, Gregory; VanBerlo, Bennett; Tschirhart, Jared; Ford, Alex; Ho, Jordan; McCauley, Joseph; Wu, Benjamin; Deglint, Jason; Hargun, Jaswin; Chaudhary, Rushil; Dave, Chintan; Arntfield, Robert
• Is Part Of: Computers in biology and medicine. Volume 148(2022)
• Publication Date: 2022-09
• Subjects: Pneumothorax -- Lung sliding -- Ultrasound -- POCUS -- Point-of care-ultrasound -- Classification -- Machine learning -- Deep learning -- Explainable AI; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2022.105953
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Pneumothorax is a potentially life-threatening condition that can be rapidly and accurately assessed via the lung sliding artefact generated using lung ultrasound (LUS). Access to LUS is challenged by user dependence and shortage of training. Image classification using deep learning methods can automate interpretation in LUS and has not been thoroughly studied for lung sliding. Using a labelled LUS dataset from 2 academic hospitals, clinical B-mode (also known as brightness or two-dimensional mode) videos featuring both presence and absence of lung sliding were transformed into motion (M) mode images. These images were subsequently used to train a deep neural network binary classifier that was evaluated using a holdout set comprising 15% of the total data. Grad-CAM explanations were examined. Our binary classifier using the EfficientNetB0 architecture was trained using 2535 LUS clips from 614 patients. When evaluated on a test set of data uninvolved in training (540 clips from 124 patients), the model performed with a sensitivity of 93.5%, specificity of 87.3% and an area under the receiver operating characteristic curve (AUC) of 0.973. Grad-CAM explanations confirmed the model's focus on relevant regions on M-mode images. Our solution accurately distinguishes between the presence and absence of lung sliding artefacts on LUS. Highlights: Convolutional neural network distinguishes lung sliding artefact on lung ultrasound. Assessment with artificial intelligence can automate pneumothorax diagnosis. The study features the largest dataset of human exams to date for lung sliding. Ultrasound experts reviewed heatmap explanations to verify model performance.