Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians. Issue 5 (27th May 2021)

• Record Type: Journal Article
• Authors: Watts, Gerald F.; Sullivan, David R.; Hare, David L.; Kostner, Karam M.; Horton, Ari E.; Bell, Damon A.; Brett, Tom; Trent, Ronald J.; Poplawski, Nicola K.; Martin, Andrew C.; Srinivasan, Shubha; Justo, Robert N.; Chow, Clara K.; Pang, Jing
• Other Names: Ademi Zanfina investigator.; Ardill Justin J. investigator.; Barnett Wendy investigator.; Bates Timothy R. investigator.; Beilin Lawrence J. investigator.; Bishop Warrick investigator.; Black J. Andrew investigator.; Brown Alex investigator.; Burnett John R. investigator.; Bursill Christina A. investigator.; Colley Alison investigator.; Clifton Peter M. investigator.; Ekinci Elif I. investigator.; Figtree Gemma A. investigator.; Forge Brett H. investigator.; Garton‐Smith Jacquie investigator.; Graham Dorothy F. investigator.; Hamilton‐Craig Ian investigator.; Hamilton‐Craig Christian R. investigator.; Heal Clare investigator.; Hespe Charlotte M. investigator.; Hooper Amanda J investigator.; Howes Laurence G. investigator.; Ingles Jodie investigator.; Janus Edward D. investigator.; Kangaharan Nadarajah investigator.; Keech Anthony C. investigator.; Kirke Andrew B. investigator.; Kritharides Leonard investigator.; Kyle Campbell V. investigator.; Lacaze Paul investigator.; CH Li Stephen investigator.; Maticevic Stjepana investigator.; McQuillan Brendan M. investigator.; Mirzaee Sam investigator.; Mori Trevor A. investigator.; Morton Allison C. investigator.; Colquhoun David M. investigator.; Moullin Joanna C. investigator.; Nestel Paul J. investigator.; Nowak Kristen J. investigator.; O'Brien Richard C investigator.; Pachter Nicholas investigator.; Page Michael M. investigator.; Psaltis Peter J. investigator.; Radford Jan investigator.; Reid Nicola J. investigator.; Robertson Elizabeth N. investigator.; Ryan Jacqueline D.M. investigator.; Sarkies Mitchell N. investigator.; Schultz Carl J investigator.; Semsarian Christopher investigator.; Simons Leon A. investigator.; Spinks Catherine investigator.; Tonkin Andrew M. investigator.; van Bockxmeer Frank investigator.; Waddell‐Smith Kathryn E. investigator.; Ward Natalie C. investigator.; White Harvey D. investigator.; Wilson Andrew M. investigator.; Winship Ingrid investigator.; Woodward Ann Marie investigator.; Nicholls Stephen J. investigator.; Elias Luke investigator.; Malan Wynand investigator.; Irvin John investigator.; Lambert Kirsten investigator.; Pedrotti Annette investigator.;
• Is Part Of: Internal medicine journal. Volume 51:Issue 5(2021)
• Page Start: 769
• Page End: 779
• Publication Date: 2021-05-27
• Subjects: familial hypercholesterolaemia -- guidance -- care -- management -- adults -- prevention; Medicine -- Periodicals; 616
• DOI: 10.1111/imj.15327
• Languages: English
• ISSNs: 1444-0903

Abstract

Abstract: Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease. New clinical practice recommendations are presented to assist practitioners in enhancing the care of all patients with FH. Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. Management is under‐pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non‐cholesterol risk factors and appropriate use of low‐density lipoprotein (LDL)‐cholesterol‐lowering therapies including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. The recommendations need to be utilised using judicious clinical judgement and shared decision‐making with patients and families. New government‐funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of the recommendations. However, a comprehensive implementation science and practice strategy is required to ensure that the guidance translates into benefit for all families with FH.