A Summary of the Prostate Cancer Prevention Trials With a Focus on the Role of Vitamin E. (February 2013)

• Record Type: Journal Article
• Authors: Abu-Shahin, Fadi; Stone, William; Ramsauer, Victoria; Krishnan, Koyamangalath
• Is Part Of: Home health care management & practice. Volume 25:Number 1(2013)
• Page Start: 23
• Page End: 28
• Publication Date: 2013-02
• Subjects: prostate -- cancer -- prevention -- vitamin -- E -- isoforms; Home care services -- Periodicals; 649
• DOI: 10.1177/1084822312453048
• Languages: English
• ISSNs: 1084-8223

Abstract

Prostate cancer is the most common noncutaneous malignancy in men. It is an excellent target for primary prevention. Vitamin E trials conducted for prevention of prostate cancer have had conflicting results with a lower incidence of prostate cancer in the ATBC trial and a higher incidence in the vitamin E arm of the SELECT trial. Most of the clinical trials with vitamin E have been limited to the alpha-tocopherol isoform alone. An increasing body of evidence suggests, however, that the gamma- and delta-isoforms of tocopherol and tocotrienols are more promising with regard to cancer prevention. This review tries to justify our assertion that the gamma- and delta-isoforms of tocopherol and tocotrienol might be superior as prostate cancer preventers.