Costello syndrome: two cases with embryonal rhabdomyosarcoma. Issue 12 (December 1998)

• Record Type: Journal Article
• Authors: Kerr, B; Eden, O B; Dandamudi, R; Shannon, N; Quarrell, O; Emmerson, A; Ladusans, E; Gerrard, M; Donnai, D
• Is Part Of: Journal of medical genetics. Volume 35:Issue 12(1998)
• Page Start: 1036
• Page End: 1039
• Publication Date: 1998-12
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.35.12.1036
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Costello syndrome is a well delineated mental retardation syndrome of unknown aetiology in which the occurrence of benign tumours, especially papillomata, is recognised. We report two children in whom the diagnosis of Costello syndrome was made in the first months of life, who both developed a retroperitoneal embryonal rhabdomyosarcoma. Although not previously reported, the occurrence of this relatively uncommon childhood tumour in two girls with Costello syndrome suggests that an increased risk of malignancy may be part of this condition. The genetic basis of this susceptibility requires further clarification.