H2 Unimolecular Elimination in Electrospray Ionization Mass Spectrometry from Erythraline, a Spirocyclic Alkaloid. Issue 5 (October 2013)

• Record Type: Journal Article
• Authors: Silva, Denise Brentan; Guaratini, Thais; Vessecchi, Ricardo; Lopes, Norberto Peporine; Cramer, Benedikt; Humpf, Hans-Ulrich; Lopes, João Luis Callegari
• Is Part Of: European journal of mass spectrometry. Volume 19:Issue 5(2013)
• Page Start: 345
• Page End: 350
• Publication Date: 2013-10
• Subjects: Erythrina alkaloids -- spirocyclic rings -- CID -- HCD -- unimolecular reaction -- erythraline -- metastable ion; Mass spectrometry -- Periodicals; Mass Spectrometry; Mass spectrometry; Periodicals; Periodicals; 543.6505
• DOI: 10.1255/ejms.1243
• Languages: English
• ISSNs: 1469-0667

Abstract

Erythrina alkaloids, which contain a spirocyclic structure, are well known due to their important biological activity at the central nervous system. In this study, systematic electrospray ionization tandem mass spectrometry (ESI-MS/MS) and ESI-multistage mass spectrometry (MS n ) analysis of erythraline have shown an unexpected H2 neutral elimination reaction. We have investigated the formation of these ions by accurate-mass ESI-MS/MS with different analyzers and the data suggest a possible unimolecular reaction of H2 loss.