Long-term tracking of fasting blood glucose variability and peripheral artery disease in people without diabetes. Issue 1 (29th September 2020)

• Record Type: Journal Article
• Authors: Sun, Xiu-Ting; Zeng, Cheng; Zhang, Shao-Zhao; Zhou, Hui-Min; Zhong, Xiang-Bin; Xiong, Zhen-Yu; Yang, Da-Ya; Guo, Yue; Zhuang, Xiao-Dong; Liao, Xin-Xue
• Is Part Of: BMJ open diabetes research and care. Volume 8:Issue 1(2020)
• Publication Date: 2020-09-29
• Subjects: atherosclerosis -- cardiovascular disease risk -- glucose metabolism -- peripheral arterial disease; Diabetes -- Periodicals; 616.462005
• DOI: 10.1136/bmjdrc-2019-000896
• Languages: English
• ISSNs: 2052-4897

Abstract

Abstract : Introduction: Long-term changes of fasting blood glucose (FBG) in relation to lower-extremity peripheral artery disease (lower-extremity PAD) in people without diabetes has barely been reported. Our study aimed to investigate the association between FBG variability and the incidence of lower-extremity PAD in people without diabetes. Research design and methods: We included 7699 participants without prior lower-extremity PAD and diabetes from the Atherosclerosis Risk in Communities study in the final analysis. At least two measurements of FBG were required during follow-up. Variability of FBG was identified using SD, coefficient of variation (CV), variability independent of the mean (VIM) and average real variability. Lower-extremity PAD was defined as an ankle brachial index <0.9, or hospitalization with a lower-extremity PAD diagnosis. Cox regression model was used to calculate HR for incidence of lower-extremity PAD and FBG variability. Results: During a median follow-up of 19.5 years, 504 (6.5 %) lower-extremity PAD events were observed, 54.4% (n=274) were male, and 17.5% (n=88) were African-American. FBG variability was positively associated with incident lower-extremity PAD, with a linear relationship. HRs for CV and VIM were 1.015 (95% CI: 1.001 to 1.03; p = 0.023), and 1.032 (95% CI: 1.004 to 1.06; p = 0.022) for lower-extremity PAD, respectively. Participants in the lowest quartile of CV were at lower lower-extremity PAD risk compared with the highest ones (HR: 1.499, 95% CI: 1.16 to 1.938; p = 0.002). Conclusions: Higher FBG variability was independently associated with increased prevalence of lower-extremity PAD in people without diabetes. Trial registration number: NCT00005131 .