Prognostic significance of DNA-binding capacity patterns in patients with lupus nephritis. Issue 5 (October 1975)

• Record Type: Journal Article
• Authors: Adler, M K; Baumgarten, A; Hecht, B; Siegel, N J
• Is Part Of: Annals of the rheumatic diseases. Volume 34:Issue 5(1975)
• Page Start: 444
• Page End: 450
• Publication Date: 1975-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.34.5.444
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : The time course of DNA binding capacity (DNA-bc) was found to correlate with the clinical course in a group of 21 patients who had biopsy-proven lupus glomerulonephritis and were treated with immunosuppressive agents. Eight patients showed a sequential DNA-bc pattern in which a high titre of anti-DNA antibody was present for a prolonged period of time all having an unfavourable clinical course. Persistently high values of DNA-bc preceded by as much as 10 months evidence of renal deterioration obtained by conventional renal function tests. Thirteen patients showed a low titre of anti-DNA antibody throughout most of their course, 12 having a favourable outcome. An initially high value of DNA-bc had no prognostic significance. These results suggest that the persistence of a high titre of anti-DNA antibody in patients with lupus glomerulonephritis is a poor prognostic sign.