Association between maternal and umbilical cord serum cobalt concentration during pregnancy and the risk of preterm birth: The Ma'anshan birth cohort (MABC) study. (March 2019)

• Record Type: Journal Article
• Authors: Li, Zhi-juan; Liang, Chun-mei; Xia, Xun; Huang, Kun; Yan, Shuang-qin; Tao, Rui-wen; Pan, Wei-jun; Sheng, Jie; Tao, Yi-ran; Xiang, Hai-yun; Hao, Jia-hu; Wang, Qu-nan; Tong, Shi-lu; Tao, Fang-biao
• Is Part Of: Chemosphere. Volume 218(2019)
• Page Start: 487
• Page End: 492
• Publication Date: 2019-03
• Subjects: Preterm birth -- Pregnancy -- Serum -- Cobalt; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2018.11.122
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Cobalt is an essential trace element and has been suggested to be involved in oxidative stress and inflammatory responses. However, researches have paid little attention to the association between serum cobalt levels during pregnancy and the risk of preterm birth (PTB, <37 week of gestation). The purpose of this study was to determine the association between maternal and umbilical cord serum cobalt concentrations and the risk of PTB. A total of 2951, 3080, and 2698 serum samples were obtained from pregnant women in the first, the second trimester, and the umbilical cord blood, respectively. The tertile levels of ln-transformed cobalt were defined as low, medium and high levels for cobalt respectively. In our study, the rate of PTB (<37 weeks of gestation) was elevated in subjects with low cobalt levels in the first trimester of pregnancy (adjusted OR 1.61, 95% CI : 1.01, 2.58) and the second trimester of pregnancy (adjusted OR 1.62, 95% CI : 1.03, 2.54). The adjusted OR for PTB was 2.46 (95% CI : 1.34, 4.53) among subjects with low cobalt levels and 2.22 (95% CI : 1.19, 4.15) among subjects with medium cobalt levels in the umbilical cord serum. Our findings demonstrated that the lower levels in maternal and umbilical cord serum cobalt were associated with the increased the risk of PTB. Highlights: The association between the maternal and fetal cobalt status and the risk of premature birth. Serum cobalt have an antioxidant and anti-inflammatory properties. High levels of serum cobalt help reduce the risk of premature birth.