Central–peripheral temperature difference, blood pressure, and arginine vasopressin in preterm neonates undergoing volume expansion. Issue 1 (1st January 1998)

• Record Type: Journal Article
• Authors: Lambert, Heather J; Baylis, Peter H; Coulthard, Malcolm G
• Is Part Of: Archives of disease in childhood. Volume 78:Issue 1(1998)
• Page Start: F43
• Page End: F45
• Publication Date: 1998-01-01
• Subjects: hypovolaemia -- albumin -- central peripheral temperature -- plasma arginine vasopressin -- systolic blood pressure; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/fn.78.1.F43
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : AIM: To examine the effect of intravascular volume expansion for the treatment of hypovolaemia in sick preterm neonates. METHODS: An intravenous infusion of 20 ml per kg of 4.5 % albumin was given to 14 preterm neonates. The effects on systolic blood pressure, central peripheral temperature difference (c-pT), and plasma arginine vasopressin concentration (pAVP) were measured. RESULTS: Thirteen babies showed a rise in systolic blood pressure. The six babies with the highest initial values of pAVP and c-pT showed a fall in both of these after infusion. The babies with lower initial pAVP (below 4 pmol/l) showed either a rise (two) or no change (six) after albumin infusion. There was a significant correlation between c-pT and log pAVP before (r 2 =0.61; p<0.05) and after infusion (r 2 =0.45; p<0.05). CONCLUSIONS: Plasma AVP concentration is related to c-pT in unwell preterm newborns. This study suggests that clinical assessment of hypovolaemia in preterm newborns is poor and could be improved by using c-pT.