Immunohistological study of granulovacuolar degeneration using monoclonal antibodies to neurofilaments. Issue 9 (September 1985)

• Record Type: Journal Article
• Authors: Kahn, J; Anderton, B H; Probst, A; Ulrich, J; Esiri, M M
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 48:Issue 9(1985)
• Page Start: 924
• Page End: 926
• Publication Date: 1985-09
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.48.9.924
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Neurons undergoing granulovacuolar degeneration have been examined in paraffin sections with three monoclonal antibodies to neurofilaments. Two of these antibodies (BF10, RT97) had been shown previously to react with neurofibrillary tangles. One of these antibodies (RT97) reacted with granular component of granulovacuolar degeneration. BF10 sometimes reacted with the surrounding neuronal cytoplasm. Granulovacuolar degeneration was also detected in a few cells of the anterior olfactory nucleus.