Single-Walled Carbon Nanotube-Based Near-Infrared Optical Glucose Sensors toward In Vivo Continuous Glucose Monitoring. (January 2013)

• Record Type: Journal Article
• Authors: Yum, Kyungsuk; McNicholas, Thomas P.; Mu, Bin; Strano, Michael S.
• Is Part Of: Journal of diabetes science and technology. Volume 7:Number 1(2013)
• Page Start: 72
• Page End: 87
• Publication Date: 2013-01
• Subjects: continuous glucose monitoring -- glucose -- near-infrared fluorescence -- single-walled carbon nanotube; Diabetes -- Periodicals; Medical technology -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1177/193229681300700109
• Languages: English
• ISSNs: 1932-2968

Abstract

This article reviews research efforts on developing single-walled carbon nanotube (SWNT)-based near-infrared (NIR) optical glucose sensors toward long-term in vivo continuous glucose monitoring (CGM). We first discuss the unique optical properties of SWNTs and compare SWNTs with traditional organic and nanoparticle fluorophores regarding in vivo glucose-sensing applications. We then present our development of SWNT-based glucose sensors that use glucose-binding proteins and boronic acids as a high-affinity molecular receptor for glucose and transduce binding events on the receptors to modulate SWNT fluorescence. Finally, we discuss opportunities and challenges in translating the emerging technology of SWNT-based NIR optical glucose sensors into in vivo CGM for practical clinical use.