Red cell folate concentrations in patients with Crohn's disease on parenteral nutrition. Issue 769 (November 1989)

• Record Type: Journal Article
• Authors: Tominaga, M.; Iida, M.; Aoyagi, K.; Kohrogi, N.; Matsui, T.; Fujishima, M.
• Is Part Of: Postgraduate medical journal. Volume 65:Issue 769(1989)
• Page Start: 818
• Page End: 820
• Publication Date: 1989-11
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.65.769.818
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : To examine changes in the folate concentrations in red cell during relatively long-term total parenteral nutrition (TPN), 10 Japanese patients with Crohn's disease (7 males), the mean Crohn's disease activity index on admission being 211, were given folic acid in a dose of 400 micrograms/day (AMA-FDA formulation) or 800 micrograms/day for 6-16 weeks (mean 10.5). The red cell folate concentrations were determined before TPN and once every week or 2-4 weeks thereafter. The folate concentrations were very low even after TPN with folic acid of 400 micrograms/day. In those given 800 micrograms of daily folic acid, the folate levels tended to increase, but did not reach the normal range. We propose that folic acid over 800 micrograms/day or a double dose of AMA-FDA formulation should be prescribed for Crohn's disease treated with long-term TPN.