Lipidomic analysis reveals the effect of passive smoking on facial skin surface lipid in females. (September 2022)

• Record Type: Journal Article
• Authors: Zhao, Mengzhen; Fan, Keliang; Wang, Jia; Wang, Juan; Xu, Qingqing; Wei, Dandan; Chen, Yuanyuan; Zhou, Lihong; Mao, Zhenxing; Chen, Tian
• Is Part Of: Chemistry and physics of lipids. Volume 247(2022)
• Publication Date: 2022-09
• Subjects: Skin surface lipids -- Passive smoking -- Glycerolipid -- Fatty acids -- Sphingolipid; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipids; Periodicals; Electronic journals; 547.77
• DOI: 10.1016/j.chemphyslip.2022.105228
• Languages: English
• ISSNs: 0009-3084

Abstract

Abstract: Background: Smoking has toxic effects on the skin and can damage it. However, few studies have focused on the lipid profile changes of facial skin surface lipids (SSL) by passive smoking. Method: A cross-sectional analytical study was conducted on middle-aged females volunteered from Henan, China to participate in the study. A total of 20 passive smoking females and 20 non-passive smoking females were recruited for this study. The components of skin surface lipids were measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF-MS). Multivariate data analysis and enrichment analysis were used to investigate the differences in facial SSL between passive and non-passive smoking females. Result: There were 1247 lipid entities identified in facial SSL between passive and non-passive smoking females. Significant differences in composition of facial SSL were observed between the two groups. After multivariate data analysis suggested, 28 significantly different lipids were identified and classified into four classes in SSL of the female cheeks. As well as 32 significantly different lipids were obtained in SSL of the female foreheads, which included three classes of lipids. Subsequent analysis revealed that the content of fatty acids (FA) in passive smoking females was significantly reduced and the content of glycerolipids (GL) and sphingolipids (SP) increased, compared with the control group. Conclusion: These results indicated that an increase in GLs and SPs of facial lipids and a decrease in FAs in passive smoking females. These changes in lipids might be associated with oxidative stress and interference with signaling pathways by substances in smoke. And passive smoking affected facial SSL and changed the content and metabolism of skin lipids. Highlights: There were 1247 lipid entities identified in facial SSL between passive and non-passive smoking females. There are good separation and significant differences in facial SSL between passive and non-passive smoking females. This study found that GLs and SPs of facial lipids were increased and FAs were decreased in passive smoking females. This study provides the basis for research on skin care and raises female's awareness of the harms of passive smoking.