Estimating EQ-5D Weights from other Trial Outcome Measures for Use in Cost-Effectiveness Studies: An Example in Patients with Frozen Shoulder. Issue 2 (April 2013)

• Record Type: Journal Article
• Authors: Neilson, Aileen R.; Craig, Dawn; Richardson, Gerry; Chuang, Ling-Hsiang; McDaid, Catriona
• Is Part Of: Shoulder & elbow. Volume 5:Issue 2(2013:Apr.)
• Page Start: 136
• Page End: 143
• Publication Date: 2013-04
• Subjects: EQ-5D -- health-related quality of life weights -- mapping -- cost-effectiveness analysis -- quality-adjusted life-years -- shoulder -- frozen shoulder -- quality of life -- pain -- randomized controlled trial; Elbow -- Diseases -- Periodicals; Elbow -- Surgery -- Periodicals; Shoulder -- Diseases -- Periodicals; Shoulder -- Surgery -- Periodicals; Shoulder -- Periodicals; Elbow -- Periodicals; Shoulder Joint -- Periodicals; Elbow Joint -- Periodicals; 617.572005
• DOI: 10.1111/sae.12000
• Languages: English
• ISSNs: 1758-5732

Abstract

Background: Health-related quality of life (HRQoL) weights, such as EQ-5D, needed for conducting economic evaluations in frozen shoulder populations are currently lacking. The present study examines the feasibility of using mapping methodology to estimate HRQoL, obtain quality-adjusted life-years (QALYs) and undertake a cost-effectiveness analysis to help inform decision-making. Methods: Patient-level data from a randomized trial in a similar population were used to undertake a mapping exercise evaluating a variety of regression modelling techniques. The Short-Form-36 component summary scores and pain visual analogue scale scores were mapped to EQ-5D. The best fit model was selected and the predicted weights were used for estimating QALYs and cost-effectiveness results. Results: The selected model explained 41% ( R 2 ) of the variation in EQ-5D weights and the estimates for interventions ranged from 0.5025 to 0.6619 at baseline and from 0.6903 to 0.7600 at 3 months. The QALYs (gained) ranged from 0.1518 to 0.1715 and the estimates of cost-effectiveness were up to £400 per QALY for steroid injection compared to physical therapy with steroid injection. Discussion: Few studies in frozen shoulder populations include HRQoL weights. We have shown that mapping can potentially take advantage of datasets in similar populations and estimate HRQoL outcomes and subsequently cost-effectiveness. The results may be uncertain but can be helpful in informing the discussion around cost-effectiveness and future areas of research.