Concise Review: Cancer Cells Escape from Oncogene Addiction: Understanding the Mechanisms Behind Treatment Failure for More Effective Targeting. (23rd May 2014)

• Record Type: Journal Article
• Authors: Pellicano, Francesca; Mukherjee, Leena; Holyoake, Tessa L.
• Is Part Of: Stem cells. Volume 32:Number 6(2014:Jun.)
• Page Start: 1373
• Page End: 1379
• Publication Date: 2014-05-23
• Subjects: Oncogene addiction -- Cancer cells -- Chronic myeloid leukemia -- Adult stem cells -- BCR-ABL -- Hemopoietic stem cells -- Tyrosine kinase inhibitors; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.1678
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract: Oncogene addiction describes the dependence of some cancers on one or a few genes for their survival. Inhibition of the corresponding oncoproteins can lead to dramatic responses. However, in some cases, such as chronic myeloid leukemia (CML), a disease characterized by the presence of the abnormal fusion tyrosine kinase BCR-ABL, cancer stem cells may never acquire addiction to the oncogene that drives disease development. The suggested mechanism(s) for treatment failure include a quiescent stem cell population capable of reinstating disease, high levels of oncoprotein expression, or acquired mutations in the oncogene. In this review, we discuss the evidence for oncogene addiction in several solid tumors and their potential escape mechanism(s) with a particular focus on CML stem cells. Stem Cells 2014;32:1373–1379