Are glomerular filtration rate estimations necessary before high dose methotrexate?. Issue 4 (1st October 1999)

• Record Type: Journal Article
• Authors: Rees, H; Hann, I M; Chessells, J M; Webb, D K H
• Is Part Of: Archives of disease in childhood. Volume 81:Issue 4(1999)
• Page Start: 339
• Page End: 340
• Publication Date: 1999-10-01
• Subjects: methotrexate -- glomerular filtration rate -- haematological malignancies; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.81.4.339
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Glomerular filtration rates (GFR) were estimated in 168 children (227 estimates) before treatment for haematological malignancies with high dose, intravenous methotrexate. Clinical management was altered on the basis of GFR in only two cases, both of whom had tumour lysis syndrome. Routine estimations of GFR do not contribute to management.