Association of Physical Activity With Bioactive Lipids and Cardiovascular Events. Issue 4 (19th July 2022)

• Record Type: Journal Article
• Authors: Hoshi, Rosangela A.; Liu, Yanyan; Luttmann-Gibson, Heike; Tiwari, Saumya; Giulianini, Franco; Andres, Allen M.; Watrous, Jeramie D.; Cook, Nancy R.; Costenbader, Karen H.; Okereke, Olivia I.; Ridker, Paul M; Manson, JoAnn E.; Lee, I-Min; Vinayagamoorthy, Manickavasagar; Cheng, Susan; Copeland, Trisha; Jain, Mohit; Chasman, Daniel I.; Demler, Olga V.; Mora, Samia
• Is Part Of: Circulation research. Volume 131:Issue 4(2022)
• Page Start: e84
• Page End: e99
• Publication Date: 2022-07-19
• Subjects: bioactive lipids -- cardioprotection -- exercise -- genetic analysis -- metabolism; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.122.320952
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : Background: To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations. Methods: PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01169259; N=1032) and validated in JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin)-NC (REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00239681; N=589), using linear models adjusted for age, sex, race, low-density lipoprotein-cholesterol, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in 2 nested CVD case-control studies: VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation). Results: We detected 145 PA-bioactive lipid validated associations (false discovery rate <0.1). Annotations were found for 6 of these BALs: 12, 13-diHOME, 9, 10-diHOME, lysoPC(15:0), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 single-nucleotide polymorphisms. From PA-related BALs, 12 are associated with CVD. Conclusions: We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.