First clinical application of a novel T1 mapping of the whole brain. Issue 6 (December 2022)

• Record Type: Journal Article
• Authors: Müller, Sebastian Johannes; Khadhraoui, Eya; Voit, Dirk; Riedel, Christian Heiner; Frahm, Jens; Ernst, Marielle
• Is Part Of: Neuroradiology journal. Volume 35:Issue 6(2022)
• Page Start: 684
• Page End: 691
• Publication Date: 2022-12
• Subjects: T1 mapping -- quantitative magnetic resonance imaging -- T1 relaxation time; Nervous system -- Radiography -- Periodicals; Neuroradiography -- Periodicals; Electronic journals; 616.804757
• DOI: 10.1177/19714009221084244
• Languages: English
• ISSNs: 1971-4009

Abstract

Background: The aim of this study was to evaluate the reproducibility and clinical value of the novel single-shot T1 mapping method for rapid and accurate multi-slice coverage of the whole brain, described by Wang et al. 2015. Methods: At a field strength of 3 Tesla, T1 mappings of 139 patients (51 of them without pathologic findings) and two repeats of five volunteers were performed at 0.5 mm in-plane resolution. Mean T1 values were determined in 18 manually segmented regions-of-interest without pathologic findings. Reproducibility of the repeated scans was calculated using mean coefficient of variations. Pathologies were grouped and separately evaluated. Results: The mean age of the cohort was 49 (range 1–95 years). T1 relaxation times for ordinary brain and pathologies were in accordance with the literature values. Intra- and inter-subject reproducibility was excellent, and mean coefficient of variations were 2.4% and 3.8%, respectively. Discussion: The novel rapid T1 mapping method is a reliable magnetic resonance imaging technique for identifying and quantifying normal brain structures and may thus serve as a basis for assessing pathologies. The fast and parallel online calculation enables a comfortable use in everyday clinical practice. We see a possible clinical value in a large spectrum of diseases, which should be investigated in further studies.