Antibodies to protein P in systemic lupus erythematosus. Issue 4 (April 1992)

• Record Type: Journal Article
• Authors: Teh, L S; Bedwell, A E; Isenberg, D A; Gordon, C; Emery, P; Charles, P J; Harper, M; Amos, N; Williams, B D
• Is Part Of: Annals of the rheumatic diseases. Volume 51:Issue 4(1992)
• Page Start: 489
• Page End: 494
• Publication Date: 1992-04
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.51.4.489
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : A synthetic peptide was used to develop an enzyme linked immunosorbent assay (ELISA) to detect antibodies to the ribosomal proteins P0, P1, and P2. Significantly increased levels of IgG antibodies to protein P were found in 16% (18/116) of patients with systemic lupus erythematosus but slightly increased levels were detected in 2% (2/98) of patients with rheumatoid arthritis and one normal control subject. No association was observed between the presence of IgG antibodies to protein P and either lupus psychosis or depression. Sequential studies in individual patients failed to show an association between antibody levels and the development of psychosis.