Azathioprine induced liver disease: nodular regenerative hyperplasia of the liver and perivenous fibrosis in a patient treated for multiple sclerosis. Issue 6 (June 1991)

• Record Type: Journal Article
• Authors: Mion, F; Napoleon, B; Berger, F; Chevallier, M; Bonvoisin, S; Descos, L
• Is Part Of: Gut. Volume 32:Issue 6(1991)
• Page Start: 715
• Page End: 717
• Publication Date: 1991-06
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.32.6.715
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Azathioprine hepatotoxicity has been described mainly in renal transplant recipients. Most reported cases are related to lesions of the venous system of the liver: peliosis hepatis, veno-occlusive disease of the liver, perisinusoidal fibrosis, and nodular regenerative hyperplasia of the liver. The most common clinical manifestation of these hepatic vascular lesions is portal hypertension. We present a case of nodular regenerative hyperplasia and perivenous fibrosis in a patient receiving azathioprine for multiple sclerosis. Histological abnormalities were similar to those described in renal transplant patients, and azathioprine was the only potential hepatotoxic agent present.