Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives. (1st April 2015)

• Record Type: Journal Article
• Authors: Santos-Pardo, Irene; Villuendas, Roger; Salvador-Corres, Iñaki; Martínez-Morillo, Melania; Olivé, Alejandro; Bayes-Genis, Antoni
• Is Part Of: International journal of cardiology. Volume 184(2015)
• Page Start: 244
• Page End: 250
• Publication Date: 2015-04-01
• Subjects: Anti-Ro/SSA -- Pathogenesis -- Cardiac rhythm disturbances; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2014.11.002
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies. Highlights: Certain antibodies could be the pathogenic basis of cases of heart block. Immunosuppressive therapy may have a role in preventing the need for pacing. These antibodies have also been linked to prolongation in cardiac repolarization.