A quantitative study of alpha-naphthyl acetate esterase-positive cells in Hodgkin's disease. Issue 12 (December 1982)

• Record Type: Journal Article
• Authors: Crocker, J; Jones, E L; Curran, R C
• Is Part Of: Journal of clinical pathology. Volume 35:Issue 12(1982)
• Page Start: 1301
• Page End: 1306
• Publication Date: 1982-12
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.35.12.1301
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : The numbers of alpha-naphthyl acetate esterase (ANAE)-positive cells (other than T cells) have been counted in 32 specimens of Hodgkin's disease and two specimens of histiocytic lymphoma. The different Rye subtypes of Hodgkin's disease contain varying numbers of enzyme-positive cells, ranging from 1.8-16% in the lymphocyte-predominant form to 39.8-47% in lymphocyte-depleted Hodgkin's disease. The percentage of enzyme-positive cells in the mixed cellularity variety was from only 6.5 to 14.6%. In the two specimens of apparently genuine histiocytic lymphoma, the enzyme-positive cells constituted 95.2 and 97.5% respectively of all cells. Thus, the numbers of macrophages and macrophage-like cells in true histiocytic lymphoma are much greater than in Hodgkin's disease.