A clinical and genetic study of Hunter's syndrome. 2 Differences between the mild and severe forms. Issue 6 (December 1982)

• Record Type: Journal Article
• Authors: Young, I D; Harper, P S; Newcombe, R G; Archer, I M
• Is Part Of: Journal of medical genetics. Volume 19:Issue 6(1982)
• Page Start: 408
• Page End: 411
• Publication Date: 1982-12
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.19.6.408
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Comparison of the disease course in patients with the severe and mild forms of Hunter's syndrome indicates that the severely affected boys show a higher incidence of behavioural disorder, diarrhoea, convulsions, and terminal cachexia. It is proposed that all of these differences may be attributed to the underlying neurodegeneration which characterises the severe form of the disease. A means of predicting the ultimate disease outcome in a young isolated case is presented.