Optic nerve hypoplasia, encephalopathy, and neurodevelopmental handicap. Issue 4 (April 1991)

• Record Type: Journal Article
• Authors: Burke, J P; O'Keefe, M; Bowell, R
• Is Part Of: British journal of ophthalmology. Volume 75:Issue 4(1991)
• Page Start: 236
• Page End: 239
• Publication Date: 1991-04
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.75.4.236
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Abnormalities of the central nervous system are frequently described in optic nerve hypoplasia. In a longitudinal study of 46 consecutive children (32 term, 14 preterm) with bilateral optic nerve hypoplasia 32 (69.5%) had associated neurodevelopmental handicap. Of these, 90% had structural central nervous system abnormalities on computed tomographic brain scans. Neurodevelopmental handicap occurred in 62.5% of the term and 86% of the preterm infants respectively. Term infants had a greater incidence of ventral developmental midline defects and proportionately fewer maternal and/or neonatal complications throughout pregnancy, while encephaloclastic lesions were commoner among the premature infants. An association of optic nerve hypoplasia with the twin transfusion syndrome and prenatal vascular encephalopathies is described.