Amino acid uptake by dorsal root ganglia from streptozotocin-diabetic rats. Issue 9 (September 1984)

• Record Type: Journal Article
• Authors: Thomas, P K; Wright, D W; Tzebelikos, E
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 47:Issue 9(1984)
• Page Start: 912
• Page End: 916
• Publication Date: 1984-09
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.47.9.912
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Dorsal root ganglia from streptozotocin-diabetic rats and age- and weight-matched control animals were incubated with 4-amino 3H-butyric acid. A significant reduction in uptake was observed in the diabetic animals. The incorporation of 3H-leucine into protein was also significantly reduced but the results did not allow a conclusion as to whether this was a secondary or an independent effect. These findings are discussed in relation both to the abnormalities known to develop in diabetic rats and to the causation of human diabetic neuropathy.