Linkage analysis of British and Indian families with Von Recklinghausen neurofibromatosis. Issue 9 (September 1987)

• Record Type: Journal Article
• Authors: Mathew, C G; Thorpe, K; Easton, D F; Carter, C; Wallis, C; Wong, Z; Jeffreys, A J; Ponder, B A
• Is Part Of: Journal of medical genetics. Volume 24:Issue 9(1987)
• Page Start: 524
• Page End: 526
• Publication Date: 1987-09
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.24.9.524
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Linkage analysis has been undertaken in two British and three South African Indian families with Von Recklinghausen neurofibromatosis. Eleven polymorphic DNA probes were studied, including both random DNA sequences and candidate oncogenes. Although no evidence for linkage of these probes to the disease was detected, substantial exclusion regions were established on six of the chromosomes studied.