Effects of long-term antihypertensive treatment on brain metabolism after bilateral carotid artery occlusion in spontaneously hypertensive rats. Issue 12 (December 1979)

• Record Type: Journal Article
• Authors: Tamaki, K; Fujishima, M; Nakatomi, Y; Ishitsuka, T; Ogata, J; Omae, T
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 42:Issue 12(1979)
• Page Start: 1141
• Page End: 1145
• Publication Date: 1979-12
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.42.12.1141
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : The effects of antihypertensive treatment on brain metabolism after bilateral carotid occlusion were studied in spontaneously hypertensive rats. The results indicate that an increase in metabolites of ischaemic brain such as lactate and the lactate/pyruvate ratio after carotid occlusion in spontaneously hypertensive rats is apparently suppressed by treating hypertension. This suggests that hypertension may play an important role in susceptibility to cerebral ischaemia.