The spectrum of Silver-Russell syndrome: a clinical and molecular genetic study and new diagnostic criteria. Issue 11 (1st November 1999)

• Record Type: Journal Article
• Authors: Price, S M; Stanhope, R; Garrett, C; Preece, M A; Trembath, R C
• Is Part Of: Journal of medical genetics. Volume 36:Issue 11(1999)
• Page Start: 837
• Page End: 842
• Publication Date: 1999-11-01
• Subjects: Silver-Russell syndrome -- uniparental disomy of chromosome 7; Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.36.11.837
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : The Silver-Russell syndrome (SRS) is characterised by severe intrauterine growth retardation, with a preserved head circumference, leading to a lean body habitus and short stature. Facial dysmorphism and asymmetry are considered typical features of the syndrome, although the range of phenotypic variance is unknown. Fifty seven subjects varying in age from 0.84 to 35.01 years, in whom the diagnosis of SRS had been considered definite or likely, were re-evaluated in a combined clinical and molecular study by a single observer (SMP). In 50 patients the clinical findings complied with a very broad definition of SRS. Notable additional findings included generalised camptodactyly seen in 11 (22%), many with distal arthrogryposis. Thirteen of the 25 males required genital surgery for conditions including hypospadias and inguinal hernia. Fourteen (36.8%) subjects above school age have received a statement of special educational needs. Molecular genetic analysis was performed in 42 subjects and has identified maternal uniparental disomy of chromosome 7 in four. The phenotype was generally milder with birth weights for one patient above and three below −2 SD from the mean. Two children had classical facial dysmorphic features, and two had a milder facial phenotype. Of relevance to the possible molecular mechanism underlying this condition, none of the four disomic patients had significant asymmetry.