Ferritin in Crohn's disease tissue: detection by electron microscopy. Issue 9 (September 1976)

• Record Type: Journal Article
• Authors: Whorwell, P J; Baldwin, R C; Wright, R
• Is Part Of: Gut. Volume 17:Issue 9(1976)
• Page Start: 696
• Page End: 699
• Publication Date: 1976-09
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.17.9.696
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Using immune electron microscopy, an attempt has been made to visualise viral particles in Crohn's disease tissue and faeces. No particles resembling viruses were observed, but in the absence of a specific antiserum a negative result does not exclude the presence of a virus, particularly if it is sparsely distributed. Compared with controls, an abundance of a 12 nm particle was found in all Crohn's disease tissue and one small intestinal lymphoma. This particle has been identified as ferritin and is unlikely to be of aetiological significance.