HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis. Issue 6 (December 1982)

• Record Type: Journal Article
• Authors: Bardin, T; Dryll, A; Debeyre, N; Ryckewaert, A; Legrand, L; Marcelli, A; Dausset, J
• Is Part Of: Annals of the rheumatic diseases. Volume 41:Issue 6(1982)
• Page Start: 599
• Page End: 601
• Publication Date: 1982-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.41.6.599
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlation was observed between gold side effects and the haplotype A1 Cw7 B8 DR3 (p less than 10(-2), RR = 8.0). In addition 3 out of 4 cases of renal intolerance to D-penicillamine were observed in patients possessing the Cw7 B8 DR3 haplotype.