Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy. Issue 652 (February 1980)

• Record Type: Journal Article
• Authors: Dandona, P.; Greenbury, E.; Beckett, A. G.
• Is Part Of: Postgraduate medical journal. Volume 56:Issue 652(1980)
• Page Start: 135
• Page End: 136
• Publication Date: 1980-02
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.56.652.135
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol. Soon afterwards he developed cholestatic hepatitis and visual disturbance. Rifampicin and ethambutol were stopped. Streptomycin caused vertigo and had to be stopped. The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma. Metformin was stopped. Hypoglycaemic coma recurred. PAS was stopped and the patient's blood glucose concentrations became normal. Treatment with isoniazid and ethambutol led to total recovery from pulmonary tuberculosis. The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.