Diketopyrrolopyrrole‐Porphyrin Conjugates with High Two‐Photon Absorption and Singlet Oxygen Generation for Two‐Photon Photodynamic Therapy. Issue 1 (4th November 2014)

• Record Type: Journal Article
• Authors: Schmitt, Julie; Heitz, Valérie; Sour, Angélique; Bolze, Frédéric; Ftouni, Hussein; Nicoud, Jean‐Francois; Flamigni, Lucia; Ventura, Barbara
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 1(2015)
• Page Start: 169
• Page End: 173
• Publication Date: 2014-11-04
• Subjects: diketopyrroles -- dyes/pigments -- photodynamic therapy -- porphyrins -- singlet oxygen -- two‐photon absorption; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201407537
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and singlet‐oxygen generation. Reported here are two new diketopyrrolopyrrole‐porphyrin conjugates as robust two‐photon absorbing dyes with high two‐photon absorption cross‐sections within the therapeutic window. Furthermore, for the first time the singlet‐oxygen generation efficiency of diketopyrrolopyrrole‐containing systems is investigated. A preliminary study on cell culture showed efficient two‐photon induced phototoxicity. Abstract : Excited! The title conjugates were prepared and characterized. They present high two‐photon absorption (TPA) cross‐sections as well as efficient singlet‐oxygen generation, thus making them interesting sensitizers for two‐photon excited photodynamic therapy.