The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families. Issue 6 (June 1994)
- Record Type:
- Journal Article
- Title:
- The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families. Issue 6 (June 1994)
- Main Title:
- The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.
- Authors:
- Teare, M D
Rohde, K
Santibáñez Koref, M F - Abstract:
- Abstract : A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.
- Is Part Of:
- Journal of medical genetics. Volume 31:Issue 6(1994)
- Journal:
- Journal of medical genetics
- Issue:
- Volume 31:Issue 6(1994)
- Issue Display:
- Volume 31, Issue 6 (1994)
- Year:
- 1994
- Volume:
- 31
- Issue:
- 6
- Issue Sort Value:
- 1994-0031-0006-0000
- Page Start:
- 448
- Page End:
- 452
- Publication Date:
- 1994-06
- Subjects:
- Medical genetics -- Periodicals
616.042 - Journal URLs:
- http://jmg.bmjjournals.com/ ↗
http://www.bmj.com/archive ↗ - DOI:
- 10.1136/jmg.31.6.448 ↗
- Languages:
- English
- ISSNs:
- 1468-6244
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 23669.xml