Psoriatic and psoriatic arthritis patients with and without jet-lag: does it matter for disease severity scores? Insights and implications from a pilot, prospective study. (2nd December 2019)

• Record Type: Journal Article
• Authors: Damiani, G.; Bragazzi, N. L.; Garbarino, S.; Chattu, V. K.; Shapiro, C. M.; Pacifico, A.; Malagoli, P.; Pigatto, P. D. M.; Conic, R. R. Z.; Tiodorovic, D.; Watad, A.; Adawi, M.
• Is Part Of: Chronobiology international. Volume 36:Number 12(2019)
• Page Start: 1733
• Page End: 1740
• Publication Date: 2019-12-02
• Subjects: Psoriasis -- psoriatic arthritis -- circadian rhythm -- human biological clock -- melatonin -- jet-lag -- PASI -- SAPASI -- DAPSA -- pruritus-VAS; Chronobiology -- Periodicals; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.1080/07420528.2019.1678629
• Languages: English
• ISSNs: 0742-0528

Abstract

ABSTRACT: Background : Jet-lag may affect air-travelers crossing at least two time-zones and has several health-care implications. It occurs when the human biological rhythms are out of synch with respect to the day-night cycle at the country destination. Its effect in psoriasis is missing. We aimed to evaluate the effect of Jet-lag in psoriatic patients' management. Methods : This is a prospective observational study that enrolled psoriatic patients that underwent a flight: patients who experienced jet-lag were compared to patients who did not experience jet-lag. Before the flight, a dermatologist recorded clinical and demographical data with particular attention to Psoriasis Area Severity Index (PASI) and Disease Activity in Psoriatic Arthritis (DAPSA). Patients performed Self-Administered Psoriasis Area Severity Index (SAPASI), the Dermatology Life Quality Index (DLQI) and the pruritus Visual Analog Scale (VAS) scores. After the flight, patients completed the SAPASI, DLQI and pruritus-VAS scores. Results : The sample recruited comprised of 70 psoriatic patients aged 42.4 ± 9.7 years (median 42.5 years). Thirty (42.9%) were males, mean BMI was 25.5 ± 2.2 kg/m 2 . Average disease duration was 15.2 ± 7.1 years, and 20 (28.6%) subjects had developed PsA. Average hours of flight were 5.4 ± 3.5 (median 3.5 h), with 34 (48.6%) subjects reporting jet-lag. At the multivariate regression analysis, the change in the SAPASI score resulted correlated with jet-lag (regression coefficient 1.63, p = .0092), as well the change in the DLQI score (regression coefficient = 1.73, p = .0009), but no change on the pruritus VAS scale was found. Conclusions : The present study suggests that jet-lag may influence disease severity and DLQI scores, but not itch in psoriatic patients.