Urinary oxalate excretion in urolithiasis and nephrocalcinosis. Issue 4 (1st April 2000)

• Record Type: Journal Article
• Authors: Neuhaus, Thomas J; Belzer, Tanja; Blau, Nenad; Hoppe, Bernd; Sidhu, Harmeet; Leumann, Ernst
• Is Part Of: Archives of disease in childhood. Volume 82:Issue 4(2000)
• Page Start: 322
• Page End: 326
• Publication Date: 2000-04-01
• Subjects: hyperoxaluria -- nephrocalcinosis -- urolithiasis -- Oxalobacter formigenes; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.82.4.322
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : AIMS: To investigate urinary oxalate excretion in children with urolithiasis and/or nephrocalcinosis and to classify hyperoxaluria (HyOx). METHODS: A total of 106 patients were screened. In those in whom the oxalate: creatinine ratio was increased, 24 hour urinary oxalate excretion was measured. Liver biopsy and/or genomic analysis was performed if primary hyperoxaluria (PH) was suspected. Stool specimens were examined for Oxalobacter formigenes in HyOx not related to PH type 1 or 2 (PH1, PH2) and in controls. RESULTS: A total of 21 patients screened had HyOx (>0.5 mmol/24 h per 1.73 m 2 ); they were classified into five groups. Eleven had PH (PH1 in nine and neither PH1 nor PH2 in two). Six had secondary HyOx: two enteric and four dietary. Four could not be classified. Seven patients had concomitant hypercalciuria. Only one of 12 patients was colonised with O formigenes compared to six of 13 controls. CONCLUSIONS: HyOx is an important risk factor for urolithiasis and nephrocalcinosis in children, and can coexist with hypercalciuria. A novel type of PH is proposed. Absence of O formigenes may contribute to HyOx not related to PH1.