Linkage studies and deletion screening in choroideremia. Issue 8 (August 1990)

• Record Type: Journal Article
• Authors: Wright, A F; Nussbaum, R L; Bhattacharya, S S; Jay, M; Lesko, J G; Evans, H J; Jay, B
• Is Part Of: Journal of medical genetics. Volume 27:Issue 8(1990)
• Page Start: 496
• Page End: 498
• Publication Date: 1990-08
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.27.8.496
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Fourteen families with choroideremia (TCD) have been examined for linkage to nine genetic markers located on the proximal long arm of the X chromosome. Linkage to three markers (DXYS1, DXS72, DXS3) located in Xq21 was found with a four point lod score of 8.25. No evidence of submicroscopic deletions was observed using DXS233 and DXS232, both thought to lie within about 1 Mb of the TCD gene.