An Integrated Approach for Experimental Design, Control, and Optimization of Perfusion Bioreactors⁎This work was supported by the VINNOVA Competence Centre AdBIOPRO, contract 2016-05181. Issue 2 (2020)

• Record Type: Journal Article
• Authors: Rodrigues, Diogo
• Is Part Of: IFAC-PapersOnLine. Volume 53:Issue 2(2020)
• Page Start: 16878
• Page End: 16883
• Publication Date: 2020
• Subjects: model -- experimental design -- control -- optimization -- perfusion -- bioreactors; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2020.12.1218
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: This paper presents methods for experimental design, control, and optimization of perfusion bioreactors as well as the vision for their integration. After describing a generic model of perfusion bioreactors, the paper proposes a control scheme via rate estimation and feedback linearization with useful properties with respect to steady-state error, stability, and performance. The paper also introduces data-driven and hybrid procedures for experimental design that are tailored to the intended use of the model for steady-state optimization. Lastly, the methods are illustrated via a simulation example of a perfusion bioreactor.