Altered quinidine disposition in a patient with chronic active hepatitis. Issue 676 (February 1982)

• Record Type: Journal Article
• Authors: Powell, J. Robert; Conrad, Kenneth A.; Okada, Robert; Guentert, Theodor W.; Riegelman, Sidney
• Is Part Of: Postgraduate medical journal. Volume 58:Issue 676(1982)
• Page Start: 82
• Page End: 84
• Publication Date: 1982-02
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.58.676.82
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : A 49-year-old female with chronic active hepatitis and ventricular ectopic activity was given i.v. 600 mg quindine gluconate (4·4 mg/kg). Quinidine plasma concentrations were analysed by high pressure liquid chromatography and plasma protein binding by equilibrium dialysis. The pharmacokinetic values were total body clearance 0·11 l/kg/hr, elimination half-life 41·5 hr, volume of the central compartment 2·26 l/kg, volume of distribution from the area under the curve 6·5 l/kg, and 19% unbound in plasma. Based on the limited information available, quinidine dosing should be markedly decreased in patients with severe liver dysfunction.